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AMY takes place in 2034 in the small town of Silver City, when natural disasters around the world have wreaked havoc on humanity and unleashed a deadly virus that has infected almost everyone. Players take on the role of Lana, who regains consciousness in the city now infested with wild creatures and enemies. The world she once identified with seems to have been torn to Hell, and most of the people she knew have now become part of a wild horde. Lana feels the virus beginning to infect her and knows she must run as far as possible to escape the nightmare. The presence of Amy, a seemingly defenseless eight-year-old autistic girl who has curious powers, forces her to make choices that will affect both their lives. Together, they must fight or run from the aberrations, demons and the military in the hope of not only saving each other, but also the future of humanity.