After saving the universe in Ratchet and Clank: Going Commando, Ratchet and Clank have been taking it easy and living the good life. Clank’s even gone and got himself a good gig as a suave secret agent on TV and in the movies. Fortunately for us, there’s never any true rest for a hero and soon Dr. Nefarious has released a plan to destroy all organic life forms in the universe with his Tyrannoids. These creatures are simple creatures with one to five eyes each and about as many brain cells, but they’re willing to kill everything else. To save the universe, the galactic president wants the man who fought Dr. Nefarious last time and sends our heroic duo off to find him on the planet Florana.