yes, if you have access to it.
if not, get your provider to do it for you.
Ok, tnx Tally
I didn't make it!
To get pb working you add the line +set sv_punkbuster 1 to your player/config_mp.cfg. If there is already a line set to 0, then your 1 command will be removed. Try searching down and finding the existing line (about 2/3 of the way down) and put the 1 in. If you are using the fs_game setting the config_mp.cfg file is under that folder not the main one.
May be unnecessary but put the following at the top of your main server cfg file:
// Punkbuster set sv_punkbuster "1" pb_sv_enable wait
Doing it thru the cofig file was not working as you would of found out if you had read all the posts properly, the best way to do it is to add +set sv_punkbuster "1" to your server start up command line if you have access to it, if not contact your server provider and ask them to assist you. Evenbalance have told me that the punkbuster settings/commands for COD2 are the same as COD so just use Romeo's link above.